Breast Cancer: One- versus three-week schedule for adjuvant whole breast radiation therapy in early breast cancer

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Breast Cancer: One- versus three-week schedule for adjuvant whole breast radiation therapy in early breast cancer

For patients receiving adjuvant whole breast radiation therapy (WBRT) for early breast cancer, conventional dosage schedules are given over several weeks, while "hypofractionated" schedules complete treatment over a shorter timeframe. In a randomized trial of over 4000 patients with early breast cancer, a hypofractionated schedule (26 Gy in five fractions over one week) reduced the rate of five-year ipsilateral breast tumor relapse compared with a conventional adjuvant schedule (40 Gy over three weeks) (1.4 versus 2.1 percent) . Further study is needed to clarify outcomes in higher-risk subgroups, who may need an additional field to cover the regional lymph nodes. Based on these and previous data, for women with early breast cancer receiving adjuvant WBRT and lacking indications for regional nodal radiation, we suggest a hypofractionated rather than conventional schedule.

Full information on Breast Cancer: https://www.uptodate.com/contents/whats-new-in-oncology#H128090

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