Oxygenation of adipose tissue in insulin resistance

Insulin resistance is associated with obesity, and increases the risk of type 2 diabetes mellitus and cardiovascular disease. However, the severity of insulin resistance is variable, even in cohorts with similar body weights. Previous work in rodent models suggested that differences in adipose tissue oxygenation could underlie this variability in insulin resistance. A new study has investigated this association in people.

The study included three groups of participants: 11 people classified as ‘metabolically healthy lean’ (MHL); 15 people classified as ‘metabolically healthy obese’ (MHO); and 20 people classified as ‘metabolically unhealthy obese’ (MUO). The researchers assessed subcutaneous abdominal adipose tissue interstitial partial pressure of oxygen (pO₂), insulin sensitivity, the expression of genes in adipose tissue associated with oxygenation and plasma concentrations of factors thought to be involved in insulin action.

The researchers found that adipose tissue pO₂ was highest in the MHL group, followed by the MHO and then MUO groups. Adipose tissue pO₂ was also found to be positively associated with hepatic and whole-body insulin sensitivity. Furthermore, adipose tissue pO2 was positively associated with the expression of genes associated with branched chain amino acid (BCAA) catabolism and negatively associated with the expression of genes associated with fibrosis and inflammation. An inverse association was found between adipose tissue pO₂ and plasma concentrations of BCAAs and PAI1.

Endocrinology and Metabolism: Open Access is a peer reviewed journal which focuses on the publication of current research and developments on the endocrine glands and its secretions with their coordination with metabolism and reproduction.

Endocrinology and Metabolism: Open Access Journal is using Editorial Tracking System to maintain quality and transparency to the author in the peer-review process. Review processing will be performed by the editorial board members of the Journal Endocrinology and Metabolism: Open Access or by Reviewers (outside experts in the field). Two independent reviewer’s approval (Minimum reviewer’s approval) followed by editor approval is obligatory for acceptance of any manuscript excluding an editorial.

Journal is now accepting manuscripts for volume 5 for year 2021. We publish minimum of 5 and maximum of 20 articles per issue every month. Submissions to our journal are given high priority during the process.

Submit your manuscript at:

https://www.imedpub.com/submissions/endocrinology-metabolism-open-access.html 

You may also send the manuscript as an attachment to mail endometabol@emedscholar.com

Media Contact
Eliza Grace
Associate Managing Editor
Endocrinology and Metabolism: Open Access
E-Mail: endometabol@emedscholar.com